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In contrast, Mounjaro trials often report lower initial rates, frequently cited between 12% and 18% at the starting doses

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Trial SURPASS-5 (JAMA 2022) Population 475 adults with T2D + insulin glargine

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The STEP clinical trial series demonstrated that weekly semaglutide 2.4 mg achieved 16.8% average weight loss in patients with obesity but without diabetes over 68 weeks, significantly better than placebo

While the study found changes in GFAP and synaptophysin, confirming structural modulation, the behavioral assay does not strictly isolate memory from reduced anxiety or improved locomotion